The airline has the rather dubious slogan, Say your goodbyes!, suggesting that passengers are unlikely to survive the flight. In addition to this, the word adios is a farewell remark in Spanish, and the airliner's logo might represent a waving hand.
No Adios Airlines airplanes are seen in Francis International Airport, but some can be found in Los Santos International Airport, including the non-pilotable Twinjets and the pilotable Jets. They are mostly yellow with small orange accents, and feature the "waving hand" logo on the tailfin, along with the Adios Airlines text on the side of the airplane's fuselage. They have a similar colour scheme to that of airplanes owned by the international mail company DHL Express, although the yellow and orange colors, as well as the airline's Hispanic origins, are likely also inspired by Iberia.
- During the mission "Marta Full of Grace" in The Lost and Damned, where Johnny has to pick up Marta from Francis International Airport, she mentions coming to Liberty City on Adios Airlines from Puerto Rico.