The house's location in Ballas territory is one of the many clues in the opening chapters of Grand Theft Auto: San Andreas that points to Big Smoke's betrayal later in the game. The first was his new car. Another one was how Carl Johnson always questioned Smoke, asking why he moved into Ballas turf and Smoke always tried to change the subject or he wanted to move away from the hood. Both the house and the car hint that Smoke has more cash than he is seemingly earning. Other clues is his future betrayal include C.R.A.S.H. officers frequently visiting his house, the fact that Smoke refused to open fire on attacking Ballas in the mission Drive-Thru, and Smoke's newly sparked rivalries with foreign gangs. All of these clues pointed towards Smoke's betrayal of Carl, Sweet and the GSF.
Since the house is never seen or mentioned again after his betrayal or his death, it is unknown what exactly happened to it.
These 4 missions are all given by Big Smoke.