- "Caligula's has been a Venturas Institution for 30 years. Has always been Mob-controlled. No sooner does one Mob get dealt with than another moves in. Currently believed to be controlled by 3 major crime families from the east coast. New manager. Just out of rehab. Possible Mob connections."
- ―GTA San Andreas Website
It is owned by the Sindacco Family, but later shared between the Leone Family and Forelli Family. It is one of the three accessible casinos, along with The Four Dragons Casino and Casino Floor. It features blackjack, roulette, video poker, and slot machines, as well as a large basement area and several hotel suites. Ken Rosenberg is the casino's manager. The casino can still be accessed and gambled in after the mission Breaking the Bank at Caligula's, in which the casino is robbed by Carl Johnson and his associates.
Caligula's Palace is based on the Las Vegas casino Caesars Palace physically and in name (Caesar and Caligula are both Roman emperors). Certain details are taken from other casinos, like the waterworks from the Bellagio (both being Italy-inspired, although Bellagio wasn't built until 1998 and Caesars Palace has an impressive water show of its own) or luminant green windows from the MGM Grand. As for its mafia management, the mafia had been mostly ran out of Las Vegas in the 1980s by the FBI, but the scenario might be based on a rumor that current casino billionaire Steve Wynn may have been connected with the Genovese crime family around 1985, all the way up to then-don Anthony "Fat Tony" Salerno.
- If you reach a 2-star or higher wanted level, policemen, or even soldiers will appear on the roof of the casino, with a number equal to the player's wanted level, shooting at the player. However, if you start walking closer to them, they will keep their distance. This could result in them falling from the roof, to their deaths as the roof doesn't have any rails, and the casino is very tall. CJ may also die if he had lost too much of his health before falling off, or being hit by explosions. If you fall off the roof, but survive, the policemen who were left on the roof will jump after the player and die. This may be a path error.
- There is a pedestrian glitch involving the peds that spawn inside the casino. If you enter the casino, shot many pedestrians, and then go up to the roof of the building by the stairs, the same peds that you killed in the casino will fall from the sky and land on the roof of the casino.