Grand Theft Auto: III
In GTA III, their first appearance is in the mission "Evidence Dash" where a CIA agent drives a Bulletproof Bobcat. The CIA also monitor the Shoreside Lift Bridge when Ray Machowski tries to flee the city by flight. They are also said to have an interest in the Cartel manufactured drug SPANK. Weapons include M-16s, and Micro-Uzis. They are portrayed as men with light skin, and dark clothes. These also appear as random pedestrians.
Grand Theft Auto: San Andreas
In 1992 they make another appearance when CJ attempts to obtain a package for Mike Toreno, and when he has to bomb a plane containing a consignment of land mines. While on board the Andromada plane they utter strange phrases that is speculated evidence of UFOs and aliens in the game.
In GTA San Andreas they appear with two different agents. One with light skin, black suit and tie, gray hair, and dark sunglasses. The other agent has dark skin, a black suit with a black tie, black hair and mustache, and black sunglasses also this agent never talks to Carl unlike the other one. These two could be a reference to the film Men In Black, or Rockstar Games placed them there to go along with the alien theme out in the desert.
For vehicles and weapons they differ in each game. In GTA III, they have various weapons. In San Andreas they have AK-47s along with the Micro Uzi. Vehicles for them are a special black Maverick and a black Bobcat.
Grand Theft Auto: Chinatown wars
Unlike other games, in GTA CW it was renamed to Agency of Centered Intelligence. Players receive the "Platinum Syringe" trophy for services rendered in powders (Cocaine and Heroin) distribution.