Bottles of Cherenkov Vodka are used as Molotov Cocktails in the game. The Cherenkov Vodka is also a sponsor in the Venturas Poker Challenge. Playboy X talks about how he loves Cherenkov Vodka in the mission "Blow Your Cover", as he talks about Russians (as he guesses that Niko Bellic is Russian.) In Broker, there is a building on the eastern side of Iroquois Ave that features a sign for Cherenkov Vodka on top of it. The second "E" and the "N" are missing, making the sign spell "Cher Kov", which is meant to be pronounced like 'jerk off', a euphemism for masturbation. Also during the opening cutscene of the mission, "Do You Have Protection?", Mikhail Faustin can be seen drinking Cherenkov Vodka.
The vodka's name is a reference to Cherenkov radiation.