Del Perro Freeway is a freeway that appears in GTA V showing his position to east. It is a part of the ingame interstate 2 and is based on the Santa Monica Freeway in Los Angeles. It begins near the Del Perro Pier, hence it's name, and heads east.
The word "Del Perro" means "Of The Dog" or "From the Dog" in Spanish. This could be a parody Del Amo Boulevard in real life Los Angeles, Del Amo literally means "Of The Owner" or "From the Owner" (as in the owner of the dog).
Interstate 2 exists as a freeway in deep South Texas