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Dwayne or Dwaine may refer to:
- 3D Universe
- Dwaine, a character in Grand Theft Auto: Vice City and Grand Theft Auto: San Andreas.
- Dwayne Thorn, host of the New World Order program on Grand Theft Auto: Vice City Stories' Vice City Public Radio.
- HD Universe
- Dwayne Forge, a character in Grand Theft Auto IV.
- Dwayne Thorne, host of the New World Order program on Grand Theft Auto: Vice City Stories' Vice City Public Radio with a star on the Vinewood Walk of Fame in Grand Theft Auto V.