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At one point late in the game, Steve Haines orders Franklin Clinton to kill Trevor Philips. Later, Devin Weston orders him to kill Michael De Santa. Franklin (the player) then has to choose which of his friends he is going to kill, or if he wants to save both of them, and kill Steve and Devin.
Choice A: "Kill Trevor"
If the player chooses to kill Trevor, the mission Something Sensible begins. In this ending, Franklin agrees to eliminate Trevor. Michael and Franklin chase Trevor. Later, Michael destroys Trevor's truck and he gets stuck under a gasoline truck. The game gives you a decision to shoot the truck or let Trevor die off. If you shoot the gas truck, it explodes, killing Trevor, Michael questions Franklin why he shot the truck. If you don't shoot him, Michael will shoot him, causing Trevor to burn to death. Michael and Franklin talk and go their separate ways. After the credits, the player can only choose to play as Franklin and Michael.
Choice B: "Kill Michael"
If the player chooses to kill Michael, the mission The Time's Come begins. In this ending, Franklin agrees to eliminate Michael. Franklin chases Michael to the top of a tower. Michael points a gun at Franklin. Franklin fights Michael and Michael falls. Franklin starts to regret his decision, but Michael refuses to forgive him and tells him to let him die. The game gives the player a decision to save Michael or let him go. But either way, Michael falls to his death. Franklin walks away and texts Lamar on the phone to make amends. After the credits, the player can only choose to play as Franklin and Trevor.
Choice C: Deathwish
If the player chooses "Deathwish", the mission The Third Way begins. Franklin, Michael and Trevor fight both the FIB’s strike team and Merryweather. Trevor then sets out to kill Steve Haines, Michael sets out to kill Harold "Stretch" Joseph, and Franklin sets out to kill Wei Cheng. After killing Haines, Trevor kidnaps Devin Weston at his house and puts him in the trunk of a car. He drives to a secluded area, and waits for Michael and Franklin to arrive. Once the three are together, they push the car off a cliff. The car hits the ground below and explodes, killing Devin. They then go their separate ways. This is the only ending in where all three protagonists survive, leaving the player the choice to play as all three.
Choice A begins at 3:30. Choice B begins at 9:12. Choice C begins at 0:00.
- For endings A and B, it is possible to attempt to spare Trevor or Michael. Not shooting Trevor will result in Michael shooting him instead, and trying to pull Michael off the silo's ledge will made him headbutt Franklin, causing him to lose his grip and fall to his death.
- For all endings, it is impossible to choose what clothing Michael and Trevor will wear. Trevor will always appear in his default outfit, and Michael will always wear his brown leather jacket and jeans.