The Desert has a few noticeable locations, like the Grand Senora National Park, Sandy Shores and the Alamo Sea. The wildlife consists of coyotes and a few bird species such as hawks.
The area has an arid climate. Weather tends to be very sunny at times. and visual heatwaves are shown occasionally. Sandstorms occur often. Rain and thunderstorms rarely occur, but when they do, the weather becomes rough and extreme. Rain is scripted to happen in the mission Friends Reunited.
The name "Grand Señora" means "Big Lady" in Spanish, referring to the dimension of the desert. Its name is most likely a reference to the Sonoran Desert. It could also be based on the Palm Desert, which is in closer proximity to the Salton Sea.