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The Hitmen make their first appearance in GTA San Andreas they appear and start to attack if the lost his/her money in gambling, also the hitmen make a small appearance in the mission Freefall, where the player gas to kill them inside the Shamal.
In GTA LCS they appear in the mission No Son of Mine, where they are hired by Toni's mother to kill her son, Toni Cipriani. However they just end up getting killed by Toni. From that point on they continue to attack Toni at random moments up until the mission Making Toni. They are depicted wearing dark suits, with gloves, and having a five o' clock shadow. They also appear to be Asian.
In GTA VCS they first appear in the mission Soldier where they murder Jerry's drug contact, and attempt to take out Vic as well. Later in the storyline they are hired by Giorgio Forelli, to attack Barry Mickelthwaite, and Phil Collins. They have the same appearance as they did in LCS. First appearing in Kill Phil, Kill Phil: Part 2, and In the Air Tonight. After In the Air Tonight, Barry decides to pay off his debt, not to take the risk of Phil being killed.
Weapons include Mac-10s, TEC-9s, AK-47s, Pistols, and M4s.