It is owned and operated by Jizzy B.. It has a large interior, with more than one floor. The Pleasure Domes served as a base of operations for the Loco Syndicate until their disbanding in 1992. The place is notorious for being the main headquarters for Jizzy's prostitution ring and keeping drug dealers as its main customers.
- "Pleasure Domes" is innuendo for breasts, as they are dome shaped, and the establishment is a strip club.
- The building is only enterable in the mission Ice Cold Killa, although the opened window on the roof remains opened throughout the rest of the game.