- Start by two B Button on the Xbox 360 (Circle Button on the PS3) punches, then one Kick with the X Button (Square Button on the PS3), then two B (Circle) punches again...Repeat the pattern to deal heavy damages as long as the opponent does not reach the ringout. And when they do, just smash B button. All opponents can be KOed in this way, especially those with knives.
- In the unlikely case you are attacked by any opponent weiding a knife, the best thing to do is to rapidly tap the block button (A for Xbox 360, X for PS3) and preform a counter attack (B for Xbox 360, X for PS3) to steal your opponents weapon. This method makes fighting in higher levels significantly more easier. Also, the weapon does not carry over to the next round. NOTE: One should NOT want to use this method against opponents using a bat due to the heavy amount of damage it deals.
- An easy way to stun any opponent is to lock on to the target with left trigger (L2 on the PS3) and stand about two body lengths away from each other, then press B once, Luis should throw a long punch to the opponents face, making then stumble backward and hold their face in pain, that is the time to land a combo, then back up and repeat.
- To easily win the first few rounds, keep your distance. Eventually, your opponent will flex and flip his middle fingers. This is your chance to throw as many punches at him as possible.
- If you aren't up for a fight, just run straight towards them and push them over and over. If they fall, don't let them get up.
- When you miss a punch or get too close, the opponent will push you aside, making the player fatigue.
- To counter, tap A (X on the PS3) to dodge as your opponent is attacking, then press either of the punch buttons B and Y (Circle and Triangle on the PS3) to counter attack.
- If you're quick, you can counter a weapon-wielding fighter and remove it from their hands.
- Be very careful when the knife fighters come out. They move very quickly and the stabs do lots of damage.
- The more health you save, the more chance you have at winning. Try to get the least amount of damage done to you in each round; make good use of dodging with the A button (X button on PS3) and counter-attacks.
- If you don't have enough health, spectate and it will be regained to full health.
- Making counters is an easy way to take out a foe in one shot, but isn't recommended when in later levels.
- If you are in need of money you can save your game and spectate then bet all your money and if you lose you can just load your game and retry this method until your fighter wins. By using this method you will be awarded the "Half Million" achievement/trophy.
- The gate where the opponents enter can be used to your advantage. If you run into the gate the same time your opponent does it may result in them being knocked to the floor or being knocked out. This may also result in your opponent walking around the arena instead of fighting this gives you a chance to attack them. Occasionally the gate may fling your opponent to a random location in the arena on the floor.
- If you stand behind the gate before your opponent gets into the ring, he will just stand there and allows you to kill him without punching back.
- Throwing combos can be risky because if you miss a punch, the enemy can quickly retaliate and drain your health. Try to throw one punch at a time to keep the opponent staggering, and unable to strike back.
- Be careful when fighting near the gate. If you accidentally walk outside of the ring, you will be disqualified.
- Each round contains three opponents.
- At the end of each round, your health is raised by 25%
- If you quit a game, the club will be closed for a while.
- When you die, you spawn at the hospital as usual but you don't lose money.
- There is a reference to The Karate Kid as spectators can be heard screaming "Sweep the leg, Johnny!"
- There is another reference to the Monkey Island Saga as certain fighters taunt you with 'You fight like a cow!', which is a signature phrase in the insult swordfighting.
- You sometimes hear someone in the crowd yell "two men enter, one man leaves," which is what the crowd chants in Mad Max Beyond Thunderdome during the fight scene in the Thunderdome.
- All of the fighters appear to be right handed since they all use an orthodox stance.
- Like Johnny, Luis uses Niko's counter attack moves, though this is due to game mechanics, as the moves were made for Niko to reflect his time in the army.
- True Crime: New York City also has a cage-fighting feature.
- If you win all six cage fight rounds, you will be awarded the title of Champion of L.C. Cage Fighters, given the "Bear Fight" achievement/trophy and also recieve $4000.
- While the game credits are rolling after completing the game, there is a scene that shows Brucie and Mori fighting in the cage, without being overly aggressive towards each other.
- Luis is unable to use his phone whilst fighting. This is so the player can't activate cheats, such as health and armor or weapons.
- Besides the point above, Luis can't fight with any weapon other than his fist, except when he counter-attacks a fighter with a melee weapon, but if the player manages to pass to the following round, the weapon will be lost.
Get Rich Quick
A good way to get a lot of money is to go into spectator mode and find out which fighters have really bad fighting techniques (i.e. swinging their arms around) and who has good ones. Keep going through the fights until there is match between someone who is bad and someone who is good. There's never a guarantee though. Never bet all your money in one go unless you're ready to lose it. So saying, you could easily double what you have (or more) by choosing the right fighter. Another good way to make money is to save your game and then bet all your money on one fighter. If you win you get loads of money, but if you lose all you have to do is reload your game and try again.
Examples of Good Fighters:
- The fat Japanese chef.
- "Both" Bikers, especially the overweight one.
- A man wearing fighting gloves (seen in the fight club introduction in Momma's Boy).
- The buff Asian guy with tattoos all over his body. He has white tank top black and white spotted pants, you can see the tattoes on his arms.
- Guy with the number "13" on the back of his tank top "sport shirt". He's bald and hispanic.
- The construction worker with the orange vest.
- The guy with the long-sleeved green shirt.
- A guy with muscle written at the back of his shirt.
- Classy guy with white shirt, blonde hair black tie, black pants and black shoes.
- The black hobo with red hat green/grey shirt and brown shoes (heavily resembles Kimbo Slice).
Some examples of bad fighters are:
Majority of those who don't fight aggresively nor headbutt, everyone that swings and punches slowly, instead of punching quickly and moving.
- Tanned guy with big muscles wearing a white tank top (aka "Pauly D, the guy that hangs around in Bahamas")
- Guy in a white overcoat.
- Guy with brown jacket and green undershirt.
- Blonde guy with red jacket, black undershirt, grey jeans and black shoes.