While better classified as a joint business venture between several criminals, the Loco Syndicate was a collective outfit dealing with drugs, primarily cocaine. The Syndicate had its main operations based in San Fierro, and was made up of San Fierro's most powerful pimp Jizzy B, Rifa gang leader T-Bone Mendez, and the mysterious businessman (later revealed to be an undercover government agent) Mike Toreno. Former Grove Street Family OG Big Smoke, who started up a large crack-cocaine empire, would later establish a business/drug deal with the Syndicate, sending his right-hand man, Ryder, and his formal representative to conduct business with them. The Loco Syndicate was the largest drug cartel in San Fierro and one of the most powerful in San Andreas, before Carl Johnson killed Ryder, Jizzy B and T-Bone Mendez. When the Loco Syndicate was consequently disbanded, Toreno returned to his usual duties and Big Smoke's narcotics empire ceased transactions with San Fierro.
As shown in the game, Mike Toreno is the Syndicate's brains and leader, calling the shots, making decisions and thinking business through. T-Bone is the muscle, he makes sure that Mike's orders, errands and deals are carried through perfectly. Finally, Jizzy is the group's face and charisma, recruiting men to pull hits, errands and other business for the Syndicate's dealings. It is indicated that Mike and T-Bone each receive 40% of the Syndicate's profits and Jizzy receives only 20% (which he complains about, although T-Bone says that he agreed to the 40-40-20 split before signing on with the group).
The Loco Syndicate also have strong ties with the local Mexican street gang; the San Fierro Rifa, as T-Bone Mendez is the leader of the Rifa. The Loco Syndicate often employ the Rifa for protection and to do small-time dirty jobs such as selling any remaining drugs on the streets - which they often pass on and sell to Los Santos gangs, especially the Los Santos Vagos.
The Syndicate most likely get their cocaine as it is smuggled into San Andreas from the harbour and airport in San Fierro. From here, they distribute and sell the cocaine to their business partners - which includes Big Smoke and the San Fierro Rifa. The Rifa and Big Smoke then sell the cocaine to the local gangs of Los Santos that are involved in drug trafficking. It is assumed that the Rifa sell the product to the Vagos as seen in the early mission Wrong Side of the Tracks, and that Big Smoke sells the product to the Ballas.
In relation to their drug partnership with Big Smoke's Crack Empire, Big Smoke sends a courier with money every Wednesday and Saturday from Los Santos to San Fierro to make the deal with the Loco Syndicate, who then return back to Los Santos to Big Smoke with the cocaine. The Loco Syndicate also operate a Crack/Drug laboratory in Doherty which is destroyed by Carl Johnson in the mission Yay Ka-Boom-Boom