- The name is mostly inspired in the fictional detective Philip Marlowe, a private detective created by Raymond Chandler. The setting in Chandler's novels were based in Los Angeles, the city Los Santos got inspired from.
- Marlowe Drive is the equivalent of the famous road (and street) "Mulholland Drive". Some rest areas can be recognize as the real Mulholland Drive that offer views on the Vinewood Sign, the Vinewood Bowl, the Galileo Observatory, the Lake Vinewood and the Downtown Los Santos.
- Marlowe drive has seven rest areas just like Mulholland Drive.