They can be found performing in the Prosperity Street Promenade. People will usually ignore mimes but sometimes, they may be seen taking pictures of them. The player is unable to speak to the mimes, but the player can cause the mimes to shout insults at the player if they anger them somehow. They are voiced by Gregg Goldston.
- Mimes have an unusual amount of health, being able to take much more of a beating than regular pedestrians. It takes approximately 4 knockout punches to take them down.