- "This ain't a rescue mission, ape. You're on your own."
- ―Steve Haines
In the mission "Did Somebody Say Yoga?", Michael has a bizarre drug-induced hallucination in which he is in an alleyway surrounded by angry monkeys.
These animals appear later on in the storyline, in the mission "Monkey Business" inside the Humane Labs and Research Facility. The monkeys are all in cages, and appear to be in a severely agitated state, possibly suffering from the effects of animal testing or due to the shootout. During the mission, at some point Haines will kick one of the cages, making a random comment before leaving. They can be shot by Michael.
A monkey actor named Chippy appears in the film Meltdown, acting as the stereotypical animal comic relief of many modern movies.
Three Masturbating Monkeys, a group of self-pleasuring monkeys, go on to win Fame or Shame.
They also appear in the movie trailer The Simian; at first one is shown being chased by the military, then many are shown invading a city, using weapons including a Minigun and even driving a Sanchez.
- Although called monkeys in the game, they are technically not monkeys at all, as this term more correctly refers to primates with tails. Instead, they are chimpanzees, a kind of ape.