The ability to use the Most Wanted list is unlocked in the mission Crime and Punishment, but if the player miraculously guesses one of the names listed below, the option "Search Police Records" can be used to find the target at any time.
When stationary in a law enforcement vehicle such as a Police Cruiser, the player can access the Police Computer and see the top ten criminals wanted by the LCPD for the current borough. The player is then able to select any of the ten listed criminals to pursue; the target will show up on the map and the player must drive there and eliminate the target(s). There is no time limit, and the missions can be re-attempted if failed.
There are thirty most wanted criminals in the game - ten in Algonquin, ten spread across Broker, Dukes and Bohan (which are counted as one borough by the police computer), and ten in Alderney City in the neighbouring state. If the player chooses a target that is too close to their current position, the mission won't start and the police computer will say "The profile is being updated". Once a mission is completed, the name is marked in red in the most wanted list - if the player tries to undertake the mission again, the police computer reports that the target is deceased, and that mission cannot be started.
Many of the targets have friends which also need to be eliminated to successfully complete the mission. Like many other missions in the game, many of the targets stay in a static location and fight Niko Bellic, but in several cases, they try to escape (depending on which mission is being played).
Completing all of the most wanted missions is required for 100% completion of the game, and unlocks the achivementManhunt. You will be notes by a message "All wanted criminals have been eliminated." after it.
All of the Most Wanted missions request the same goal: eliminated all the targets. That means you can search a good sniper spot and hunts them one by one with your sniper rifle, rains them with rocket launcher or grenades or molotov cocktails, drive-by and run over them with a truck, all you need is kill.
Also, no matter who kills the targets, the mission completed by all of them eliminated. You can calls Dwayne for backup for your cannon fodders, roadkill by peds, blown up with their car, friendly fire (RPG ver.), fall from height or stair.
In rare case, any cops near the location will attacks the nearest attacker, even while any wanted level. Unlike the Vigilante missions, usually there is no cop near the target's location, after arrived the emergency call (911) will send no cop to your place, and unable access the police car's call-backup function. Sometimes after killed half of the targets, cops or police car spawn near the location and gives you a wanted level. In this situation you can simply lure the cops to your targets, let the cops eliminated the rest of them, and the wanted level will be cleared after the mission completed.
Hollowback St, South Bohan - He is just one block north of the safe house in Bohan.
Target: 2, escape by vehicle, (if get out of vehicle) escape on foot
As you near him he will pull out and drive away.
Maxwell runs much slower than others.
Shoot him and his friend. Aim for the driver and the tires. If you cannot aim precisely, just fill the car with bullets until they bail out.
To save ammo and time, shoot the driver so that the passenger leaves the car, allowing you to take him out with ease.
As soon Maxwell and his friend drive off in their car, shoot the driver (Maxwell) in the head. Then his friend will get out of the car and close the doors. When he does that, shoot him. The mission will be complete. If you want extra money, pull Maxwell's body out of the car and he will drop $200.
Steinway, Dukes - He and his gang are hiding out in Steinway, in the large park (outdoor pool) to the west.
Target: 4, stay & shoot, 3 with pistol & 1 with micro smg
Go to the road east of them then hop over the wall. There is a small wall down here that will give you cover. Take all four of them out from up here.
Since the gang use powerful weaponry, keep an eye on your health and take full advantage of the cover given.
When you approach them from the upper site near a Unique Stunt Jump, you will see one guy walking towards the rest. It's Guzowski himself. Shoot at him and he will drop money and a Micro-SMG. The rest of them shouldn't be a problem because they are only carrying pistols. When you kill them, Scott is acknowleged as dead.
Target: 5, stay & shoot, 1 to 2 may chase their target
There is a chance Antonio get up and stay on the railroad.
Go there and go up the stairs. He has three helpers with him. Be careful as it is very crowded. Once you start start firing, innocents will come pouring down the stairs, so be careful not to the hit them. Be sure to hide behind any cover given to avoid the lethal shotguns they carry.
As you go to his location, one of his friends will go to the entrance, and start shooting at you with a pistol. Then when you kill him, you will encounter two of his friends, and Rivette himself. Antonio is the very fat one most of the time with a beard and he aims at you with a Micro-SMG. When all are dead, the mission is passed.
They always run separately, at least by two groups.
They will go north and split up at the end of the street. Kill them before that happens to save time.
As soon he and his Spanish Lords allies hear your siren, they will split up and run away. Kill his friends with a Micro Uzi or SMG and run after the Jamaican man in a suit. It's Rodrigo himself (strangely using a different ped model). When he's off the building, kill him. He'll drop some cash which you can pick up and the mission will be complete. Alternatively, you can just throw 2-3 Molotov cocktails making them burn to death.
Target: 7, stay and shoot (pistol, shotgun, micro smg)
Approach it from the southeast. As you go down the road, stop and pull out a sniper rifle. From up here you can kill a fair number of them already. With their ranks thinned, go down and take out the rest.
The cops are likely to join in on this one, if they do, wait for them to get killed and carry on or maybe if you're lucky, the cops will do your dirty work if you have already taken out the closer targets.
Target: 1, escape by vehicle (Banshee), (if get out of vehicle) chase & shoot
As soon as you get close, he will make a run for it in a Banshee. At first he is rather slow. Try to get close and shoot him out of the driver's seat. If that does not work he will speed up. Pump bullets into his car until it breaks down so he goes on foot or it explodes.
Try to go in with the PIT maneuver & then take him out before he regains control of his Banshee.
Northwood, Algonquin - He is in the northern area of the X building in Northwood, the same one Dwayne is at.
Target: 1, lay on ground, (if woke up) escape on foot
Enter it through the south and use the stairs, just to the right and then around the corner to your left. On the first floor you will notice that the red target icon changes from an up arrow to a circle. That means you are on the correct floor. Ignore everyone else and shoot Jimmy in his room as he lays there passed out.
The men around the Kand's apartment are unarmed, but sometimes if you take Jimmy out, they will attack you, so before you ice Jimmy, aim your gun at each of his friends to scare them away.
Fishmarket South, Algonquin - He and his gang hide out in Fishmarket South in the building with the sign Pier 45 on it that looks like a "#" sign on the map.
Target: 6, stay & shoot (separately)
You will find them all over the different levels of this building and they move around. Watch the radar closely to get their positions to find them all. Do not worry if cops show up, as you can also kill them. Your wanted level goes away as soon as you kill the last of the gang.
Simon seems to be a senior member of the Angels of death as he is guarded by many of them. Take them all out before they damage your health too much & ignore the heat, it always dissapears once you've eliminated all targets.
Target: 3 escape on foot, (later) escape by vehicle, (if get out of vehicle) stay & shoot
As you approach the blip, they will run to the east in that alley then go north to an SUV parked there. If they make it, they drive off and you have to chase them down. Two easy ways to kill them are to drive into that alley and run them over; or drive to the alley in the north and as they go for the SUV and kill them. This also has the advantage that you will block the SUV in case they do make it there.
Take a big car like a patriot & ram all three criminals straight into the wall before they escape.
Target: 3, escape by vehicle (NRG 900 x3), (if off the bike) stay & shoot
When you get close, three bikes will take off from there to the east. Stand where they come out and gun them down before they can get anywhere. Kill any that you can. If one makes off, chase him. Bump the bike to make him fall off, then drive over him or shoot him.
If it takes over half a minute to kill one escapee who has fallen from his bike, the others will be long gone. Go for headshots with a pistol instead of the SMG for a more accurate shot.
Purgatory, Algonquin - He hides with five of his friends in a parking garage in Purgatory. You can get up there over a ramp to the south.
Target: 6, 5 chase & shoot, 1 stay & shoot
When you get the red targets, stop and get out of the car. Take out your sniper rifle and shoot the people from this distance. Stand east of the barrier. By doing this, they will most likely not have a chance to hit you. You can also use the RPG on one of the cars to decimate them, but sniper is cheaper and almost as effective.
While the arms deal is going, get out a launcher, get behind your vehicle & fire in between the two cars to kill most of the dealers, but to finish the odd survivor, use a sniper rifle to pick them off.
East Holland, Algonquin - He is in a building just south of the three X buildings in East Holland. The entrance is on the north side, to the very east of the building. When you stand in front of it, the entrance is to the left and to the right is a blue banner on the buildings reading "Real Loose Clothing".
Target: 6-7, stay & shoot, 2 may chase Niko
The first one is just on the first landing. The second one is on the other side where the steps go up again. Exactly one level above that one is the third person. The next level is clear. Another person stands at the landing of the next level. Then, go up to the door leading to the roof. Shoot the door and immediately to the right behind it is the next person. The last person hides on the roof, to the right around the corner and behind a small wall when you get out there.
Use the cover system as effectively as possible to avoid sudden death.
Another building next to the target's building is access-able, you can get to that rooftop and get a better cover to kills the targets next rooftop.
Fishmarket South, Algonquin - He is in a building in Fishmarket South, just north of the Broker Bridge near the waterfront, with a lot of garbage trucks parked to the south. One of the story missions also brings you to this exact building.
Target: 7-8, stay & shoot
Snipe them from the south, just when you get past the fence. Anything that is not reachable that way (for example, the person in the upper level just to the left when you enter) needs a close up visit. The rest should fall easy prey to the sniper without you getting hit.
There is a side door be another way to get in.
Alderney City: Acter, Tudor, Berchem, Normandy and Leftwood
Drive to the first street to the south of the one in front of the shop. You can use a rocket launcher to blow up the car in front, doing a lot of damage to them. However this is very expensive with little pay off. Instead, use the sniper rifle and kill what you can from here. They will not come at you.
Get closer and clean up those still hiding once you blast their car & if performed correctly, You can do this without a single shot hitting you with ease.
These people also stay in place, around the large tanks close by. Watch the map to see targets that are above you, but most are on ground level. The last two hide between the containers to the southwest.
Take cover behind your car or a wall far away from Danny & his crew of bloodthirsty gunmen. Get out a sniper rifle & pick off all of the targets visible. Then, get close to the guys you just iced & fire at the rest who are taking cover behind the Containers.
Berchem, Alderney - He sits with his friends in two Patriots to the west of the TW@ Internet cafe.
Target: 4, 2 escape by vehicle & drive-by (Patriot), 2 chase Niko & drive-by (Patriot)
Approach them from the north using the street just east of the blip. When you get the red targets, get out of the car with an assault or carbine and target the men in the cars. You should be able to kill at least one of them by doing this. They often also stop, and you can easy pick all four off the streets. If they get moving, get in your car again and hunt them down. They drive very close here around the blocks all the time. You can also try to wait at a corner and blow them up with a rocket launcher, but that is unnecessary expensive.
Start shooting at the Patriot in front. Once the the driver & passenger of the front patriot are dead, time to kill the others, but remember to keep in mind that they are skillful with their SMG's & will take you out easily if you are not careful. If you decided to attack the patriot behind, the driver would stop & by the time you iced them, you are likely to have lost the patriot in front.
Tudor, Alderney - He and his friends hide in Tudor, near the old bridge.
Target: 9, stay & shoot
One of the men is to the south under the bridge itself. The rest all hide up on the bridge. As you go up, check behind you. They like to shoot you in the back. Use your sniper rifle when you can see them from afar.
Tread with caution, as this carjacker has a huge crew of assault rifle wielding Jamaicans ready to get a clean shot or two at you. Give them a taste of their own medicine, but if you run in & try to blow the heck out of them, you'll get pumped full of bullets & be dead before you know it.
Leftwood, Alderney - He and a lot of his gang are hiding out in a multi-storey car park in Leftwood, slightly to the north from the Pay And Spray.
Target: 9, stay & shoot
Go to the southwest corner here and enter through the door in the south wall. In here is a Sprunk soda machine. If you need some health while doing this, it will help. Go through the next door to the north. Follow the ramps just slightly to your right. Go up the levels. There are a few hiding behind pillars here, but the main force is on the roof. As you get sky above you, use your sniper rifle and shoot them. The last of them make a stand in the northeast corner. Remember the Sprunk machine at the entrance to refill your health if needed.
Go in with a car & try to run over the hapless targets. You will likely be hit a few times through your car window, but if your speed is right, they'll flip over your vehicle before they have time to take too much health from you. By the time you get to the second to last storey, get out of your car, use it for cover & blast the lot of them & for a quick getaway, use the ramp near the fire escape on the top level.
Reach the place by Taxi
It is possible get to the criminals' location by Taxi. Marking a waypoint on the target (because the destination will off if you get out of the police vehicle), then taking a taxi there makes your journey quicker and it won't matter that you don't taking by police car, as the game simply prompts you to "Take out all the targets".
However some of the criminals (01, 05, 10, 11, 14, 16, 17, 24, 25, 28) will escape by vehicle, that means you still need a vehicle to chase them, unless you can eliminated the drivers before they fled out of range.
(14. Tommy Francovic) Because a single shot can take the target off his bike, it is possible stop him right there and prevent the car chase.
(16. Lino Friddell) If you run fast enough, you can kill all of the target before they get on the vehicle.
(17. Juan Haimo) You can simply shoot down one of the target, and then get on his bike to chase the others. Also it is possible shoot all of them off the bike before they leave the starting point.