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|South end:||Olympic Freeway|
|North end:||Senora Freeway|
The Palomino Freeway begins in Los Santos as an interchange going off the La Puerta Freeway. The freeway leaves Los Santos and runs between the Palomino Highlands and the Tataviam Mountains and ends at a junction with the Los Santos Freeway, where the Senora Freeway continues.
- The name of the freeway is a clear reference to the town of Palomino Creek in GTA San Andreas.
- Although signed on ramp signs and the official print map as Interstate 4/Route 15, signs along the road are marked as Interstate 4/Route 13, where Route 13 is actually the the Los Santos and Senora Freeways.