- it is a good idea to buy this Safehouse when doing the Mafia missions with the mission location just across the road.
- Along with the Casino name as "Pimp". The Safehouse name can be abbreviated as "PIMPS"
- Pirates in Men's Pants is a parody of the Opera The Pirates of Penzance.
- Its name and location on the Las Venturas strip is also a parody of the pirate themed Treasure Island Hotel and Casino located on the Las Vegas strip in Clark County, Nevada.