- "High-impact pistol that delivers immense power but with extremely strong recoil. Holds 9 rounds in magazine."
- ―GTA V description on the Rockstar Games Social Club.
The weapon is a bonus to those who purchased either the Special or Collector's Edition and is available for free in game at Ammu-Nation. It will also be available to buy with in-game currency in the enhanced version of the game from any Ammu-Nation store. However, the players who bought the Special/Collector's edition of the original game will still get it for free. It is chambered in .50 caliber.
The Pistol .50 takes the form of a Desert Eagle, with a multitude of changes made to the design: besides the removal of the famous "Beaver Tail", the slide-mounted safety has been removed, the frame mounted slide release is missing, the cocking serrations on the gun are chunkier, an underbarrel rail has been added, the barrel lock has been omitted, a sliding safety has been added in place of the slide release and the trigger guard has been redesigned. In addition, the muzzle has been shifted downwards towards the middle of the barrel, and is noticeably larger in diameter. It takes the place of the Combat Pistol from previous games. It holds 9 rounds per magazine, which is inaccurate as the Desert Eagle chambered in .50 holds 7 rounds per magazine (the same inaccuracy is present in Grand Theft Auto IV). It has tritium-illuminated iron sights (like the Pistol and Combat Pistol) that are based on other modern combat pistols such as the FN Five-seven
The Pistol .50 has the highest damage per shot of pistols, and a standard semi-automatic rate of fire. Capacity is lower than that of the Pistol but it can be freely improved to be on par with it. It is available at level 1 in GTA Online and is free, making it a powerful weapon to begin with. The main weakness of the Pistol .50 is its accuracy, which makes it ineffective for drive-by shooting and of a limited efficiency while on foot. However this handgun remains effective against NPCs in close quarters. This is a good weapon for quickly finishing the first waves of a survival as a single shot to the chest is able to kill enemies at lower survival waves.
- Suppressor: Free
- Flashlight: Free
- Rounds x24: $57
- Extended Magazine: Free
- Black (default) - Equipped by default
- Army Tint (Desert sand) - Free
- Green Tint - Free
- Orange Tint - Free
- LSPD Tint (Metallic Blue) - Free
- Pink Tint - Free
- Gold Tint - Free
- Platinum - Free
- The Pistol .50 is notable for having a very high recoil; when fired, it will blow the player's hands upwards heavily.
- This is not present in the Next-Gen version while in FPS mode, however, as it kicks backward rather than upward when firing in first person. This was likely done to make it more accurate when in first person.
- The extended magazine is far larger than it should be. It is roughly twice as long, while holding only +33% bullets than the regular one. The size would have been correct if the regular clip had only 7 bullets. This may be a reference to the GTA IV scene when Niko shoots 12 bullets out of his Desert Eagle, which only holds 9 ingame.
- The Pistol .50's beta model much more resembles its real life counterpart than the final product. It was possibly changed to avoid copyright issues.
- Its sound is similar to GTA IV's Pistol .44. Additionally, both weapons work in a similiar way, having similar magazine capacities (9 for the Pistol .50, 8 for the Pistol .44), both have a high recoil, both have the name of their caliber in the name and both share the record for being the most powerful pistols in the games they appear.
- The Pistol .50 on the Xbox 360/PlayStation 3 platforms had an error where the reload sound effect would be almost completely silent. On the Xbox One/PS4 and PC platforms, this has been fixed.
- The Pistol .50 appears to be based on a custom built Desert Eagle, rather than the actual production version.