The Portland Safehouse in Grand Theft Auto III is the first place the player can save at.
The safehouse is situated in a backalley in the Red Light District, consisting of one rudimentary living space (depicted being equipped with a bed, stove, washing machine, microwave and television, and a garage capable of containing up to one moderately sized vehicle). Awarded baseball bat, police bribes, a health pickup, an adrenaline pill, as well as pickups attained by collecting hidden packages are usually sorted within the backalley. In addition, completion of "Big'n'Veiny" from El Burro will result in the safehouse appearing with stacks of bestiality pornography magazines (presumably a gift from El Burro).
Based on the sign hung over its garage, the safehouse is associated with one "Eddie". Upon escaping police custody, Claude and 8-Ball use this place to "lay low" during "Give Me Liberty". In Grand Theft Auto: Liberty City Stories, a hidden package is found behind a couple of trashcans next to the safehouse's door.