The safehouse is a basic apartment that was given to the player during "Home Sweet Home" by Vincenzo Cilli, and can only be accessed from the rear, through a back passage. The safehouse only features one working garage that can only hold one vehicle (much like its Grand Theft Auto III equivalent), despite featuring two garage doors. But, a motorbike can be fit into the garage by parking the bike close to the garage door, getting on the bike, then quickly driving the bike into the garage (notice that the garage might move up and down at a fast speed, but not shutting all the way.) Some versions of the game though does not allow the bike to be placed inside, the bike disappearing right after the garage closes. A hidden package can be found on the roof of an extension next to the entrance into the safehouse and the baseball bat pickup, and is only reachable by parking a large vehicle, such as an Ambulance, next to the extension and climbing up the vehicle. Additional pick-ups become available as certain missions and sub-missions are completed.
The safehouse is depicted with a small interior comprising three rooms: The living space, which functions as a living room and dining room and contains the safehouse's save point; the kitchen, which contains a health pickup; and the bedroom, which contains a wardrobe icon. An open window looks out onto the street below, where pedestrians can be viewed walking and having discussions; Toni can't interact with them or attack them, though if he fires a weapon inside the safehouse, the pedestrians will react accordingly (it is not possible to get a wanted level within the safehouse, however). Pedestrians and vehicles can be destroyed using a sniper rifle, but other firearms will not work.The safehouse's design is based on partially demolished ruins at the same spot in GTA III, implying the safehouse was eventually cleared out and was in the process of being torn down by events in GTA III in 2001.
A glitch in the PS2 version of the game causes the garage to not always open, requiring several approaches before it will open and allow access. An identical glitch occurs with the Doherty Garage in Grand Theft Auto: San Andreas.