The museum is located on the eastern edge of Middle Park (similar to the Met's location in Central Park), fronting Columbus Avenue and Middle Park East, Algonquin, Liberty City. At the time of the game's setting, the musuem is under renovation and is closed to the general public. It features various pieces of historic exhibits (some of which are yet to be unpacked or are covered), as well as skeletons of three dinosaurs in the main lobby.
In IV and TLAD, the player may gain access into the building through a side door on the southern side of the museum (The North Entrance is inaccessible except in Collector's Item where Johnny enters), through a path that leads to the museum floor. The lobby and the mezzanine, and loading backrooms are the only areas inside the museum that are accessible, but the player may also reach the rooftop of the museum on foot via a series of scaffolding outside the museum, on the west side of the building. As the museum is closed to the public, the front doors are locked.
The Libertonian's name is a play on "Smithsonian".
The location is used in "Museum Piece", "Collector's Item" and "Not So Fast", where Niko Bellic and Johnny Klebitz meet Isaac Roth and his associates in a diamond deal on the second floor. However, Luis Lopez opens fire on the diamond deal ensuing a chaotic escape for the dealers.
Grand Theft Auto IV
Niko Bellic drives to the museum, meeting Johnny Klebitz at the side, then they both head in. After the deal is ambushed Niko shoots his way out, killing Ancelotti goons before escaping.
The Lost and Damned
Johnny Klebitz drives to the museum, he waits at the side for Niko Bellic, the two head in. After the deal is ambushed Johnny takes the 2 million in cash, betraying Ray Boccino, he kills Boccino's goons and escapes.
The Ballad of Gay Tony
Luis Lopez arrives via Buzzard, landing on the roof, he scopes out the deal, and then attacks. He steals the diamonds off of Isaac Roth, then escaps with the Buzzard before taking out pursuing police helicopters in the air.
- There is an easter egg in the museum; the plaque describing the Tyrannosaurus Rex. The texture of the text is low-resolution, and thus hard to read properly, but reads, roughly, "This big bastard took a few days to knock up because it had to be done by the sole hand of a prop artist. But alas, and feast your eyes on this 21,000 poly maniac. Trex right up your arse. How do you like them apples?"
- "Impossible Trinity" at Youtube.