- "Mankind has fucked its cousin... one last time."
- ―One of the movie's taglines
The Simian is a fictional film produced by Browne Canyon within the HD Universe. The movie is rated PA for Post-Apocalyptic Nonsense and contains "bestiality, awesome graphic violence, clichés, and product placement." Its theatrical trailer is attached to Meltdown, the feature film produced by Solomon Richards and Michael De Santa in Grand Theft Auto V. The plot and several shots in the trailer are clear references to Rise of the Planet of the Apes, the 2011 reboot of the Planet of the Apes series. Although the movie is unviewable by the player, its trailer is played in the Astro Theaters and the Oriental Theater of Los Santos.
After an attempt of extracting monkey DNA has gone terribly wrong, apes declare war on the human species, wreaking havoc on streets of Los Santos, Blaine County and Liberty City. The monkeys in the movie are depicted as incredibly agile warriors with good weapon wielding and driving skills.