Like other police stations in the game, the Vespucci Police Station serves as a respawn point if the player is Busted in the area. The Vespucci Police Station is a modern three-story building which is based on the real life Santa Monica Public Safety Facility.
The following vehicles can be found at the Vespucci Police Station:
- A Body Armor can be found on the garage rooftop patio.
- In GTA Online, the station's parking lot was a location for Pegasus Lifestyle Management vehicles to spawn.
- As of patch 1.17, the spawn location was abolished, and now spawns further down the road in a construction site parking lot.
- On a wall on the Vespucci Canals side of the station is graffiti that reads "police and thieves in the street." This is a reference to the Junior Murvin reggae song 'Police and Thieves', which was covered by British punk band The Clash. A dub version of the original reggae song, 'Grumblin' Dub' is featured in-game on Blue Ark.