The Combine Harvester is designed as a drivable combine harvester more suited for farm use, being distinguishable by its wide revolving combine head that moves as the Combine Harvester is moving. Its resulting wide width and weight, coupled with a rear wheel drive configuration, makes the Combine Harvester difficult to control, navigate on populated roads, and store in regular garages. The vehicle is only available in maroon.
A unique ability of the Combine Harvester is its capability to dismember pedestrians when the player runs him/her over, and then discharge the body parts and gore/blood through an outtake towards the rear. However, CJ himself cannot be dismembered or gored through by a moving Combine Harvester. Goring police is a quick way to earn high wanted levels.
The Combine Harvester makes its first appearance in the mission "Body Harvest" when Carl Johnson is asked to steal one by The Truth while it is operating at a farm. Upon completion, Combine Harvesters will appear all over San Andreas.
Due to its use as a farming equipment, the Combine Harvester is exclusively found in farmland, specifically Blueberry Acres, The Farm and Flint Range. At day, the harvesters will be seen operated by a driver and moving along a predetermined route in the fields; at night, the harvesters are parked in the fields.
Almost all encountered Combine Harvesters, especially those at night, are locked, making the vehicle very difficult to steal. In order to obtain one, one may shoot a Combine Harvester's driver at the head, killing them and resulting in the driver falling out and leaving the vehicle's door open for the player to steal. Two can be found at Helena Wankstein's Farm in Flint Range, although they're difficult to obtain because they're constantly moving around a crop.
- When the player has a wanted level, driving the combine harvester has an advantage as the doors of the harvester are locked when the player is driving it and therefore it is impossible for the police to bust the player. However due to the combine harvester's fragility, doing this at wanted levels above two stars in not recommended as it can be easily destroyed using firearms.
- At one point during development, the Combine Harvester had a green body color, no stepbars into the driver cab, and a less detailed combine head.
- It is impossible to place Satchel Charges on the vehicle, as they pass straight through it.