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This is the first out of five assassination missions that Franklin is asked to do by Lester. In the Hotel Assassination, Lester asks you to go to a hotel and assassinate Brett Lowrey, CEO of Bilkinton Research, while Lowrey is leaving the Von Crastenburg Hotel in Richman.
Lester suggests two ways of killing Lowrey, by shooting him with a sniper rifle or with bombs. It does not matter which option you choose to complete the mission.
Invest in Betta Pharmaceuticals on the BAWSAQ stock exchange with Michael, Franklin and Trevor before starting this assassination mission, then sell your stock after 2 in-game hours once you have completed the mission.