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Giggle Cream is a dessert topping mentioned in Grand Theft Auto: Vice City and Grand Theft Auto IV. The topping is a mixture of whipped cream and nitrous oxide (commonly known as "laughing gas", hence the name). The product is advertised on the radio in GTA: Vice City with the tagline "Makes dessert funny". Apparently, it killed 23 people, leading to a ban by the FDA. In GTA IV, Giggle Cream can be seen being sold illegally on yourmexicandoctor.com.
- It seems to be a parody of Reddi-wip, a canned whipped topping that also utilizes nitrous oxide.
- Giggle Cream is mentioned on VCPD radio chatter in Grand Theft Auto: Vice City. An officer (possibly Jones) states that a suspect with Giggle Cream was causing trouble, and that he gave him a little beating.
- The beginning and end of the radio advertisement appears to parody the chorus of No Limit by 2 Unlimited, which was released in 1993.