In GTA San Andreas, Helmut Schein markets perfume, advertising "Shine Perfume" in an avant-garde manner on the radio, parodying real-life perfume commercials during the 1990s. If listened to closely, the person in the commercial is that of Jodie Shawback, who does the voice of Sage, the host of Radio X.
In GTA Liberty City Stories, players can find a Helmut Schein outlet in Chinatown, Portland, Liberty City circa 1998, which is sold off by 2001. Advertising for the company can also be found near Francis Intl. Airport, showcasing their furniture.
Another Helmut Schein in GTA Vice City Stories can be found at the Vice Point Mall in Vice Point, Vice City circa 1984 on the northwestern wing of the mall beside Flyingdale's, complete with a detailed interior, although it cannot be entered. The store is also later sold off by 1986, and replaced by an unmarked clothing business.
While the Helmut Schein storefront in GTA Liberty City Stories is devoid of any interior or details to indicate its type of business, the GTA Vice City Stories Helmut Schein's interior contains sofas, coffee tables, and two counters, hinting that it may also be a furniture store similar to KLÜNT.
- Helmut Schein is a faux-German play of the saying "Helmet Shine". The slogan for the company is "Polished to Perfection!", another reference. Sales for the company in GTA: Liberty City Stories also claim that the sale is "the big one", a further reference.
- The billboard for the company in GTA: Liberty City Stories shows what appears to be a blue-filtered screenshot of the beta Mulholland Safehouse from GTA: San Andreas.