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The house is located in the district of Glen Park, Los Santos. It appears only during the mission Doberman, in which Little Weasel is seen emerging from the house shortly before he is murdered by Carl Johnson.
Since Little Weasel had defected to the Ballas from the Grove Street Families, and Glen Park wasn't Grove Street territory before the "Doberman" mission, it is possible Weasel resided elsewhere during his time with the Families.
The interior of the house is not seen, and is inaccessible to the player.
Little Weasel's House appears in the following missions: