The Madrazo Cartel are a Mexican gang that appears in Grand Theft Auto V.
Their only appearance as a gang are in the level "Marriage Counseling", one of Michael De Santa's missions, where they attempt to kill Michael after he pulled down the deck of a property which Martin Madrazo had an interest in. The hitmen chase Michael and Franklin Clinton to Michael's Rockford Hills mansion, where the last of them are gunned down. However, Martin beats Michael down and tells him that he owes him $2.5 million. Afterwards, Michael pays his debt off and makes a business relationship, but they are enemies once more when Trevor Philips kidnaps Patricia Madrazo and steals Martin's car after he refuses to pay him for killing Javier Madrazo. They are again reconciled when Michael sends him an Aztec Fertility Idol that he stole from a train and Trevor returns his wife to him.
La Fuente Blanca, a ranch owned by Martin Madrazo, serves as the Madrazo Cartel's main area of operation. Cartel members can be seen standing guard or patrolling the ranch. Martin also owns a house in Vinewood Hills, which appears in many online missions.