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- The name is mostly likely inspired in the fictional detective Philip Marlowe, a private detective created by Raymond Chandler. The setting in Chandler's novels were based in Los Angeles, the city Los Santos got inspired from.
- Marlowe Drive is the equivalent of the famous road (and street) Mulholland Drive. Some rest areas can be recognized as those on the real Mulholland Drive, offering views of the Vinewood Sign, the Vinewood Bowl, the Galileo Observatory, Lake Vinewood, and Downtown Los Santos.
- Marlowe Drive has seven rest areas just like Mulholland Drive.
- It is possible that Marlowe Drive is named after a prominent unseen family in the game, as the Marlowe Vineyards are also in the game