Mike drives Misty and two other female prostitutes to "high-rolling" clients, on orders from 8-Ball, in an attempt to find out information about the death of Vinnie. She later moves to Staunton Island and begins working for Yakuza co-leader Asuka Kasen, meeting Mike again when is sent by Asuka to deal with a pimp who had been stalking some of her girls.
The player can choose Misty as a mother of their online character in Grand Theft Auto Online, if they purchased the Collectors Edition of Grand Theft Auto V or if they are a returning player transferring characters from the original version of the game.
Misty is in many ways similar to Grand Theft Auto IV's character Lola Del Rio. They are both prostitutes that are featured in nearly every promotional artwork for their respective games. The only difference is that Lola is an unseen character and was only used to promote the game, while Misty did appear in GTA III and GTA Advance.
During the missions Luigi's Girls and Drive Misty For Me, the player can have Misty attack other non-playable characters by attacking them. Misty also makes statements such as "Leave me alone! Hey!".
Misty is viewed as something of a mascot for Grand Theft Auto III due to her prominent role in the game's promotion.