The hotel is located in Downtown, Vice City. In 1984, the setting of GTA Vice City Stories, the hotel is being built, with the building finished in 1986, the setting of GTA Vice City. In GTA Vice City Stories, a Rumpo, Bulldozer and Flatbed can normally be found on the site, along with a red balloon. An unique stunt jump and police bribe can also be found on the site. By 1986, the hotel has opened. An area of water had been placed at the front of the hotel, whilst the back of the hotel has become a car park.
The term "Moist Palms" refers to lubrication of the palms before masturbation.
- The Moist Palms Hotel's looks are based on the now demolished Miami Heralds headquarters in Miami.