The Pavano crime family is the second-most powerful of the Mafia families on the Liberty City Commission. The Pavano's are primarily based in Algonquin. The family is said to be controlled by 60 year old Mary Valvona, along with her 40-year-old ex-lover Arthur Zepulla who is the family's official consigliere. Mary Valvona and Zepulla are suspects in the murder of her former husband and boss Mario Valvona in the 1990s. The Street boss was Joe Corrola until his death in 2008. He was in charge of the family's heroin distribution ring. Mario Venturella is the longest lasting lovers of Mary and is an Algonquin based cat-burglar. Vito Menotti, a former Pavano hitman turned states against them in 2008.
Don Jimmy Pegorino looked at the Pavano Family as a way of getting a seat on the Commission, so he organized a sit down with them at an old refinery, where he took Niko Bellic along to watch over the meet with a sniper rifle after he was recommended to Pegorino by Phil Bell. The sit down was a set up and the Pavanos attempted to whack Don James Pegorino, who was saved by Niko. After this, the Pegorinos and the Pavanos went to the mattresses, and the Pavano Family later suffered for their actions when Pegorino hired Bellic to wipe out one of their crews that was meeting at Auto Eroticar in Alderney City.
- Mary Valvona — 60 year old female boss (or Front boss), after her husband Mario's death (she was suspected to have poisoned him, but no one knows for sure). Most of the top-ranking members are her lovers, all at least 20 and usually even 40 years younger than her.
- Arthur Zepulla — 40-year-old, ex-lover of Mary Valvona, in the early 90s Mary paid for him to go to law school and he might possible be involved in the murder of former boss Mario Valvona. Currently the family's consigliere, he could also be the unofficial boss of the family, allowing Mary to take the media attention as the Front boss.
- Joe Corrola — Mary's 38-year-old lover who was in charge of the family's heroin distribution ring.
- Vito "Dog Meat" Menotti - a top-ranking hitman for the Pavanos since the 1990s, who is now turning states against them.
- The Pavano family is similar to a Italian Camorra organization, which once had a female boss named Rosetta Cutolo.
- Mary Valvona, could be based on Rockstar games interpretation of Cathy Moriarty-Gentile character Patti LoPresti from the film Analyze That were she was a female Mafia Boss in New York City. No Italian-American crime families in New York City or the United States ever had any female members. Females have only stayed as associates or "Comare" (name for mafia mistress).
- The Pavano family could also be loosely based on the Genovese crime family. The Pavano's are operating in some of the same areas as the Genovese's, in Manhattan (Algonquin) neighborhoods of Harlem (North Holland), and Central Park (Middle Park) the family also maintains a strong presence in New Jersey (Alderney). The Pavano family is ranked as the second-most powerful family in GTA IV, while the Genovese crime family is ranked as America's most powerful mafia family. In a Liberty Tree article the Pavano's are mentioned to be rivals of the Gambetti's (Gambino family), similar to the real Genovese-Gambino rivalry.
- It is possible that Mary Valvona is not the real boss of the Pavano Family and is in fact just a patsy for for the real (male) boss. For years the Genovese family (on which the Pavanos are likely based) used Anthony "Fat Tony" Salerno as the front boss or "puppet boss" for the real boss Vincent "The Chin" Gigante.
- The lastnames from two members of the Pavanos Valvona and Corrola might be a reference to famous Italian delicatessen "Valvona & Crolla " in Edinburgh, Scotland, UK.
- The Pavano Family's main/favorite car is probably the Sultan because many appear in Pegorino's Pride.
- In the mission Payback, some goons fighting Niko are actually the Irish Mob.