Carl goes to Smoke's house. Upon arriving there, he finds Officer Frank Tenpenny and Officer Eddie Pulaski leaving. Smoke informs Carl that they are attempting to extract information from him. Smoke tells CJ that his cousin, Mary is coming to the town from Mexico and he's going to pick her up.
The two drive to a place to meet two Vagosgang members. After a short mixed Spanish conversation, Smoke knocks one out using a baseball bat while the other runs away. Carl manages to catch and kill him.
Now that ain't nice. Coughio up el weedo, before I blow your brains out all over the patio.
Chinga a tu madre, pendejo.
Man, let me get the heater on this... Get him Smoke!
Yeah, yeah, you go get that shit, nigga... (hits Vago with Baseball Bat) Yeah, motherfucker, Big Smoke! Remember that name!
CJ chases the remaining Vago and once he kills him the mission is complete.
It is a good idea to get your stamina up before doing this mission.
CJ will have infinite sprint if the Burglary mission is done beforehand.
This mission may become difficult if the player is overweight or obese.
For a really easy completion, steal the Clover north of your position and run him down.
The Sawn-off shotgun is an excellent choice for this mission, since it can be fired while running. One can be acquired from a spawn point atop the Pig Pen.
It can also be obtained, along with the Molotov, the AK and Tec if you have sprayed all 100 tags.
If you know where the Sentinel spawn point, you can destroy the car first before the Vagos gang member approach it and then you can kill him. You can approach the car by entering the spawn jetpack cheat.
Despite there being no monetary reward, the player can collect about $500 after killing the Vagos member.
Big Smoke says his cousin is called "Mary", which is a reference to Mary Jane, slang for marijuana.
This is the only mission given by Big Smoke where Carl is not required to use a motorbike. (However, even though he is required to use a yellow Sanchez in the next mission, he does not need to.)
During this mission, if you just follow the gang member in a car, he will enter in a Sentinel with another member and will shoot you if you get close.
The line the second Vagos member uses roughly translates to, "fuck you, bastard," and afterwards, "fuck your mother, dickhead."
The place where Carl and Big Smoke park is the same place where Carl and Sweet park to discuss their plans for Big Smoke during End of The Line.
In this mission it's revealed that Big Smoke knows how to speak (some) Spanish.
Earlier during the game's development, this mission also required Carl to drive Smoke back home. CJ asked Smoke about Tenpenny's visit at the start of the mission, which Smoke replied that he does not know who Tenpenny is. It is speculated that part was cut because it was too strong foreshadowing to Smoke's betrayal. 
If the player fails the mission and he's too fat during it, a phone call has received from Big Smoke. Seen in this video
Officer Frank Tenpenny and Officer Eddie Pulaski leaving Big Smoke's house.