At the very beginning of the game, she is married (her fourth marriage) to Kirk Simplex for a mere twenty minutes. Their marriage ceremony cost $50 million, featured her thirteen foreign children in heritage costumes, and A-Z List magazine paying $15 million for exclusive coverage.
After her failed marriage, Muldoon switched religions three times in one week (from Buddhism to Kabbalah to Epsilon). She has fourteen adopted children from various countries, the most recent is a baby from Sub-Saharan Africa which she returned due to its constant crying; Another child, "Wave", who had grown to be eight years old and was given a faux-hawk, wasn't seen for some time and was probably sent home as well.
Events of GTA V
Sometime after the events of GTA IV she took up Christianity, a fake southern accent, right-wing views and transitioned from pop to country music. In 2013, Muldoon attempted suicide by ingesting a bottle of vodka with a fistful of pills, after a recent breakup and struggles in her career (she later tried to pass it off as an accident). A few months after the incident, she appeared on the radio show Bless Your Heart with Bobby June. She tells Bobby June that her adopted children still number at thirteen, who "each have their own room and their own name!". She debuts a song from her new album, I Like Things Just the Way They Are. During the mission Paparazzo, Beverly Felton mentions that there are rumors of Samantha buying an North Korean baby through the black market.