The hospital is located in the Portland View district of Portland Island, Liberty City. The hospital was opened in 1847 according to its sign and it is the only hospital on Portland Island. The hospital was partly founded by Trans-Plant, the organ retrieving specialists. The slogan of the hospital is Because HEALTH is LIBERTY.
The hospital is located next to the Liberty City Police Department's Portland headquarters. Two health icons and an Ambulance appear at the hospital in all three games the hospital appears in. In GTA III, an Adrenaline Pill is also available on hospital grounds and in GTA Liberty City Stories a hidden package is located at the back of the hospital. If the player activates the Perfect Traction cheat in GTA LCS, at the front of the hospital there is a place where an Esperanto and an Angel spawn. If the player uses a car to jump to the taller roof (just beside the place where the Angel spawns) and continues to drive or walk, you will fall into blue hell for three to five seconds and respawn at either Portland View or Chinatown.
- If the player manages to explore Liberty City in GTA San Andreas, they can see the hospital.