The Science of Crime is a television series in Grand Theft Auto IV shown on CCC. The Science of Crime is a parody of the popular CBS series CSI: Crime Scene Investigation and its spin-offs, of which there are apparently fifteen in GTA IV. Mentioned spin-offs include Science of Crime: Vice City, Las Venturas, Ohio, Tuskegee, Djibouti, Fairbanks, Panama City, Santiago, etc., which may be a reference to CSI's over-expansion on other cities.
On the radio, adverts and billboards, the show is proclaimed to be "forensically boring!" The show is well-advertised: adverts on the radio, seen on rooftop advertisements on the Declasse Taxi and a billboard above the tollbooths on the East Borough Bridge.
- A Science of Crime theme tune can be purchased from www.vipluxuryringtones.com and used as a phone ringtone. It starts with a distinctive yell similar to that found in The Who's "Won't Get Fooled Again," the theme from CSI: Miami.
- The person in the adverts bears an strong resemblance to Talbot Daniels, which the ped model itself resembles Dr. Sheldon Hawkes from CSI: NY.
- TSoC may also be a parody of the hit TV franchise Law and Order, which also is known for its many spin-offs and expansions to different cities.