They Crawled from Uranus is a minigame in Grand Theft Auto: San Andreas, available in the form of one of the game's four arcade games. They Crawled from Uranus arcade machines are scattered throughout interiors of buildings in San Andreas, including bars, nightclubs, 24-7 stores and Madd Dogg's Crib. The game is also available in home console form, such as on the CJD 500 in the Johnson House.
They Crawled from Uranus is similar in gameplay to Gyruss, in which the player is only able to move around a central space and shoot towards the center. The player assumes the role of a space pilot aimed at destroying advancing and retreating alien crafts that fire at the player from the center of the screen. By destroying every strand of enemy ships, a warp token will appear for the player to pick up; though not necessary, attaining three such tokens will send the ship "warping" to the next level, where enemy ships move in more unpredictable paths and fire at the player more frequently; players will also score higher individual points at higher levels.
- The game does not appear with its own arcade cabinet, and as a result uses Go Go Space Monkey's cabinet, as seen on those in 24-7s outlets.
- The game's double entendre title (Uranus = Your anus) appears to mirror the design of the game; the central void where the aliens emerge from is comparable to an anus.