The Uptown Riders are a motorcycle gang featured in The Lost and Damned. Their members include Malc and DeSean and they are based in Northwood. The club rides Japanese sport bikes and appear to be predominately African-American, much like the real life Ruff Ryders.The Uptown Riders did not appear in Grand Theft Auto IV, but are present The Lost and Damned.
Even though Malc seems to be allied with The Lost Brotherhood The Uptown Riders will still attack Johnny if he is armed.
On The Lost and Damned you can challenge the Uptown Riders to arm wrestling, although, similair to the Angels of death ,if you are armed, or approach them on a bike, they will attack you.