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- "Coughio up el weedo, before I blow your brains out all over the patio."
- ―Melvin "Big Smoke" Harris, to the Vagos members
The gang members appear only during the mission Running Dog. CJ and Big Smoke go to East Los Santos and meet the two. They engage in a short conversation, and Smoke proceeds to beat one member up with a Baseball Bat while CJ chases and kills the other member.
Big Smoke calls one member Jose, although he was most likely just being racist, as "Jose" is a common Spanish name.
The gang members appear in the following mission:
- Running Dog (killed)