The Wheelchair is a very slow 'vehicle' in the GTA London games, Grand Theft Auto: London 1969 and Grand Theft Auto: London 1961. Its speed is just as fast as a pedestrian walking and is definitely not the best getaway vehicle. It can be spotted near hospitals. However an explosive-ridden wheelchair features predominately in one of the missions.
There is also an unusable wheelchair in Grand Theft Auto: San Andreas located at the end of a dock/pier in Fisher's Lagoon. It has the same model texture as some trash dumpsters that can be found around the San Andreas. This wheelchair is most likely an easter egg.
- Trev, a member of rock group The Ambulance in GTA Vice City Stories, is confined to a wheelchair after an accident.
- Johnny Sindacco is confined to a wheelchair in GTA San Andreas after a heart attack during the mission Fender Ketchup. He later dies when falling out of his wheelchair due to another heart attack during The Meat Business.
- Angus Martin is confined to a wheelchair in The Lost and Damned, after Billy Grey caused an accident that crippled him.
- Lester Crest uses a wheelchair in Grand Theft Auto V due to his health condition. However, when he can't use it, he uses a cane.