Headquartered in the Downtown district of San Fierro, San Andreas, its building is one of the largest and distinctive in the district; featuring an accessible glass foyer and a colossal decorative sculpture shaped after a DNA strand at the center of the building. Towards the rear are elevators that lead to different levels of the building, with some interestingly marked as an entry to a zombie lab.
The Zombotech Corporation attempts to soften its sinistry and inhuman corporate image by posting the following inscription on its lobby entrance: "Zombotech Sinister Zombie Virus Research Corporation Welcomes Visitors!". However, no pedestrians can be seen walking inside the building lobby.
The headquarters is featured in the mission Jizzy, where Carl Johnson is ordered to drop off one of Jizzy B.'s girls in front of the building. During this mission, Jizzy claims that the building is a hotel, whether or not there actually is one operating in the building alongside the corporation or it is simply a mistake by the developers.
- Camera - By one of the pillars at the lobby.
- One snapshot - At the large central DNA strand sculpture